Freeonlinetranslators News

Gene therapy reverses rat’s paralysis

14 июня
17:39 2018
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Media captionParalysed rat picks up sugar cube after gene therapy repairs spinal cord

Scientists say they have taken a significant step towards the goal of giving paralysed people control of their hands again.

The team at King's College London used gene therapy to repair damage in the spinal cord of rats.

The animals could then pick up and eat sugar cubes with their front paws.

It is early stage research, but experts said it was some of the most compelling evidence that people's hand function could one day be restored.

The spinal cord is a dense tube of nerves carrying instructions from the brain to the rest of the body.

The body repairs a wounded spinal cord with scar tissue.

However, the scar acts like a barrier to new connections forming between nerves.

How the gene therapy works

The researchers were trying to dissolve components of the scar tissue in the rats' spinal cord.

They needed to give cells in the cord a new set of genetic instructions - a gene - for breaking down the scar.

The instructions they gave were for an enzyme called chondroitinase. And they used a virus to deliver them.

Finally, a drug was used to activate the instructions.

The animals regained use of their front paws after the gene therapy had been switched on for two months.

Dr Emily Burnside, one of the researchers, said: "The rats were able to accurately reach and grasp sugar pellets.

"We also found a dramatic increase in activity in the spinal cord of the rats, suggesting that new connections had been made in the networks of nerve cells."

The researchers hope their approach will work for people injured in car crashes or falls.

Prof Elizabeth Bradbury told the BBC: "We find this really exciting, recovery of this type of function, because for spinal injured patients their highest priority is to get their hand function back.

"Being able to pick up a coffee cup, hold a toothbrush, these types of things will have a dramatic increase on their quality of life and their independence."

In 2014, a paralysed man was able to walk with a frame after cells from inside his nose were used to regenerate part of his spinal cord.

The patient, Darek Fidyka, was injured in a knife attack that caused a different type of wound to those in car crashes.

The gene therapy approach is not yet ready for human clinical trials.

Dr Mark Bacon, from the charity Spinal Research, told the BBC: "The data is some of the most compelling I've seen demonstrating restoration of skilled forelimb function.

"It's exciting, but getting approval for gene therapies represents a particular, but not insurmountable, challenge to getting it to the clinic.

"Transferred to the clinic, this research could be life-changing for the millions of people worldwide with paralysis caused by a spinal cord injury."

Follow James on Twitter.

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  104. "свежие вакансии на сегодня" 21 октября, 10:03

    {
    {Я был / я был} {серфинг|просмотр} онлайн более {трех|3|2|4} часов сегодня, но я так и не нашел ни
    одной интересной статьи, подобной вашей.
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    {По моему мнению|лично|на мой взгляд}, если все {веб-мастера|владельцы сайтов|владельцы веб-сайтов|владельцы
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    {Хорошо|Отлично|Хорошо|очень хорошо} написано!|
    {Я|я} {сразу|сразу} {взять|схватить|сцепления|схватить|задержать|схватить}
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    {ссылка|гиперссылка} или {бюллетень|электронный бюллетень} обслуживания.
    Есть ли у вас что-нибудь? {Пожалуйста|пожалуйста} {позволяют|разрешение|дай} мне {понять|признать|понять|признать|узнать} {дабы|дабы} я {может|может|может} подписаться.
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    {Это|Это} {подходящее|идеальное|лучшее} время строить
    какие-то планы на будущее и {это|это} время
    быть счастливым. {Я прочитал
    этот пост, и если бы я мог, я бы {хотел|хотел|хотел бы} предложить вам {несколько|некоторые} интересные вещи или {советы|предложения|советы}.
    {Возможно|возможно} вы {могли бы|можете}
    написать следующие статьи, ссылаясь на эту статью.
    Я {хочу|желаю|желаю} читать {больше|еще больше} вещей об этом!|
    {Это|Это} {подходящее|идеальное|лучшее} время для составления {нескольких|некоторых} планов на {будущее|долгосрочную|долгосрочную
    перспективу} и {это|это} время быть счастливым.

    {Я|я} {прочитать|узнать} это {сообщению|отправить|опубликовать|мириться} и если
    я {может|может|может} Я {хочу|желаю|желаю} {предлагаю|рекомендую|советую} вам {несколько|некоторые} {интересные|увлекательные|привлекающие
    внимание} {вещи|проблемы} или {советы|предложения|советы}.
    {Возможно|возможно} вы {могли бы|можете} написать {следующие|последующие} статьи {относящиеся|ссылающиеся|касающиеся}
    этой статьи. Я {хотите|хотите|желание} {прочитать|узнать} {еще|еще} {вещи|вопросы} {примерно|о} к!|
    {Я|я} был {серфинг|просмотр} {онлайн|он-лайн} {более|больше} {три|3} часов {в
    эти дни|в настоящее время|сегодня|последние|последние}, {однако|но} Я {никогда|ни в коем случае}
    {не нашел|не обнаружил} ни одной {интересной|увлекательной|привлекающей внимание} статьи, подобной вашей.
    {Это|это} {прекрасный|довольно|красивый} {стоимость|стоимость|цена} {довольно|достаточно}
    для меня. {На мой взгляд|лично|на мой взгляд}, если все
    {вебмастеры|владельцы сайтов|владельцы веб-сайтов|владельцы веб-сайтов} и блоггеры
    сделали {просто правильно|хорошо|отлично} {контент|Контент-материал} так,
    как {вы сделали|вы, вероятно, сделали}, то {интернет|сеть|веб} {будет|будет|может быть|может быть|вероятно
    будет} {гораздо больше|намного больше} {полезно|полезно}, чем когда-либо
    прежде.|
    Ahaa, его {хорошо|Хорошо|хорошо|привередливый} {обсуждение|разговор|диалог}
    {о|О|О|на тему} это {статья|сообщение|сочинение|пункт}
    {здесь|в этом месте} в {блог|Блог|веб-страница|веб-сайт|веб-сайт}, я прочитал все,
    что, так {сейчас|в данный момент} мне также
    комментируя {здесь|в этом
    месте}.|
    Я уверен, что эта {статья|пост|кусок письма|абзац} коснулась всех интернет-пользователей {людей|зрителей|посетителей}, ее действительно очень {приятно|приятно / хорошо|привередливо}
    {статья|пост|кусок письма|абзац}
    по созданию нового {блог|Блог|веб-страница|веб-сайт|веб-сайт}.|
    Ничего себе, эта {статья|пост|кусок письма|абзац} {хороша|приятна|хороша|привередлива}, моя {сестра|младшая сестра} анализирует
    {такие|эти|эти виды} вещей, {так|так|поэтому}
    я собираюсь {рассказать|сообщить|дать знать|передать} ей.|
    {Сохранено как избранное|закладка в закладки!!}, {мне очень нравится|мне нравится|мне нравится} {ваш блог|ваш сайт|ваш веб-сайт|ваш сайт}!|
    Очень круто! Некоторые {очень|чрезвычайно} действительные пункты!
    Я ценю, что вы {пишете это|пишете это} {статья|пост|запись} {и|а
    также|плюс} остальная часть {сайт есть|сайт есть} {также очень|чрезвычайно|Очень|также действительно|действительно} хороши.|
    Привет, {я действительно верю|я действительно
    думаю} {это отличный|это отличный} {блог|сайт|веб-сайт|сайт}.

    Я споткнулся об него 😉 {Я так и сделаю|Я собираюсь|я собираюсь|я могу} {вернуться|вернуться|вернуться} {еще раз|еще раз}
    {так как я|так как у меня есть}
    {закладка|книга помечена|книга помечена|сохранена как
    избранная} это. Деньги и свобода {это лучший|величайший} способ измениться, пусть вы будете богаты и продолжаете {помогать|направлять} {другим людям|другим}.|
    Ого! Я действительно {люблю|наслаждаюсь|копаю} шаблон/тему этого {сайта|сайта|блога}.
    Это просто, но эффективно. Очень часто бывает {очень трудно|очень трудно|сложно|трудно|трудно / трудно} получить этот «идеальный баланс» между {превосходным юзабилити|удобством использования|удобством использования} и
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    Я должен сказать {что вы|вы|вы сделали
    {потрясающую|потрясающую|очень хорошую|превосходную|фантастическую|превосходную|великолепную}
    работу с этим. {Кроме того|дополнительно|также}, блог загружается {очень|чрезвычайно|супер} {быстро|быстро} для
    меня на {Safari|Internet explorer|Chrome|Opera|Firefox}.
    {Превосходный|Исключительный|Выдающийся|Отличный} Блог!|
    Это {действительно|на самом деле|на самом
    деле|по-настоящему / искренне} {великие|огромные|впечатляющие|замечательные|фантастические} идеи в {отношении|отношении|О|по
    теме} блоггинга. Вы затронули некоторые {хороший|приятным|хорошо|привередливый} {моменты|факторы|} вещи здесь.
    В любом случае продолжайте извиваться.|
    {Я люблю|мне действительно нравится|мне нравится|мне нравится|все любят} то,
    что вы, ребята, {обычно|склонны быть} тоже.
    {Такого рода|такого рода|такого
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    Продолжайте в том же {превосходные|потрясающие|очень хорошие|отличные|хорошие|отличные|фантастический|отлично|удивительный|замечательный} работает ребята
    я {включены||добавленную|включены}
    вы, ребята, {|мое|наше||мое личное|мои собственные} блоге.|
    {Привет|привет там|Привет там|Привет|Привет|Привет}!
    Кто-то в моей {MySpace|Facebook} общая это {сайт|сайт} с нами,
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    Я определенно {наслаждаюсь|люблю} этой информацией.

    Я {book-marking|bookmarking} и буду чирикать об этом
    своим подписчикам! {Прекрасный|замечательный|идеальный|потрясающе|великолепно|исключительное|превосходное|отличное} блог {замечательный|прекрасный|блестящий|удивительные|отлично|отлично|потрясающе|великолепно|превосходно} {стиль и дизайн|дизайн
    и стиль|дизайн}.|
    {Я люблю|мне действительно нравится|мне нравится|мне нравится|все любят} то, что вы, ребята,
    {обычно|склонны быть} тоже. {Такого рода|такого рода|такого рода
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    хорошие|отличные|хорошие|отличные|фантастический|отлично|удивительный|замечательный} работает ребята я {включены|добавлены|включены} вы, ребята,
    {|мое|наше|мое личное|мои собственные} блоге.|
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    Я {просмотр|планирование|собирается},
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    {Я люблю|мне действительно нравится|мне нравится|все любят} это {когда люди|когда люди|когда люди|когда люди} {собираются вместе|собираются вместе} и делятся {мнениями|мыслями|взглядами|идеями}.

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  105. Noi Ta Den
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